Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore

CLF Pooley, JP Edwards, ME Goldman…

Index: Journal of Medicinal Chemistry, , vol. 41, # 18 p. 3461 - 3466

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Citation Number: 57

Abstract

... Journal of Medicinal ... Departments of Medicinal Chemistry, New Leads Discovery, and Endocrine Research, Ligand Pharmaceuticals Inc., San Diego, California. J. Med. Chem. ... Chemistry. The initial lead, LG001447 (3), was screened for activity on various intracellular receptors. ...