Synthesis leading to novel 2, 4, 6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines

PM Chandrika, T Yakaiah, B Narsaiah, V Sridhar…

Index: Chandrika, P Mani; Yakaiah; Narsaiah; Sridhar; Venugopal; Rao, J Venkateshwara; Kumar, K Pranay; Murthy; Rao, A Raghu Ram Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 6 p. 840 - 847

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Citation Number: 40

Abstract

A series of novel 2, 4, 6-trisubstituted quinazoline derivatives 6 have been synthesized from anthranilic acids 1 in five steps via benzoxazinones 2, N-benzoyl benzamides 3, quinazol-4- ones 4, 4-chloroquinazolines 5. Products 6 have been screened for antibacterial and cytotoxic activity, promising compounds have been identified. Keywords: Benzoylation, acylation, cyclisation, quinazolones, quinazolines

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