Tetrahedron letters

Total synthesis of (−)-martinellic acid

V Badarinarayana, CJ Lovely

Index: Badarinarayana, Vivek; Lovely, Carl J. Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2607 - 2610

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Citation Number: 32

Abstract

An enantioselective formal total synthesis of the pyrrolo [3, 2-c] quinoline natural product martinellic acid has been achieved. The key steps involve a Pd-catalyzed aryl amidation reaction of a pyrroglutamate derivative, an intramolecular [3+ 2] azomethine ylide–alkene cycloaddition and a reductive ring opening reaction.