An Efficient Large-Scale Process for the Human Leukocyte Elastase Inhibitor, DMP 7771
L Storace, L Anzalone, PN Confalone…
Index: Organic Process Research and Development, , vol. 6, # 1 p. 54 - 63
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Citation Number: 30
Abstract
... will discuss in turn the synthesis of fragments 1 and 2 and conclude by describing a procedure for their ... A total of 190 kg of DMP 777 were prepared by this process. ... completion criterion of less than 5% of 6). The lower (aqueous) layer was separated, and the organic phase was ...
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An Efficient Large-Scale Process for the Human Leukocyte Elastase Inhibitor, DMP 7771
[Storace, Louis; Anzalone, Luigi; Confalone, Pat N.; Davis, Wayne P.; Fortunak, Joseph M.; Giangiordano, Mark; Haley Jr., James J.; Kamholz, Kenneth; Li, Hui-Yin; Ma, Philip; Nugent, William A.; Parsons Jr., Rodney L.; Sheeran, Patrick J.; Silverman, Charlotte E.; Waltermire, Robert E.; Wood, Christopher C. Organic Process Research and Development, 2002 , vol. 6, # 1 p. 54 - 63]
[European Journal of Medicinal Chemistry, , vol. 31, # 11 p. 895 - 899]
[European Journal of Medicinal Chemistry, , vol. 31, # 11 p. 895 - 899]
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