Tetrahedron letters

Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-α, α-disubstituted amino acids

J Cianci, JB Baell, AJ Harvey

Index: Cianci, Julia; Baell, Jonathan B.; Harvey, Andrew J. Tetrahedron Letters, 2007 , vol. 48, # 34 p. 5973 - 5975

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Citation Number: 12

Abstract

Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids.