Asymmetric total synthesis of nigerone

…, EC Dugan, CA Mulrooney, MC Kozlowski

Index: DiVirgilio, Evan S.; Dugan, Elizabeth C.; Mulrooney, Carol A.; Kozlowski, Marisa C. Organic Letters, 2007 , vol. 9, # 3 p. 385 - 388

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Citation Number: 41

Abstract

An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative biaryl coupling of an advanced intermediate with a 1, 5-diaza-cis-decalin copper catalyst.