Bioorganic & medicinal chemistry letters

SAR studies of 2-o-substituted-benzoyl-and 2-alkanoyl-cyclohexane-1, 3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase

Y Lin, C Wu, S Lin, D Yang

Index: Lin, Yung-Lung; Wu, Chung-Shieh; Lin, Shean-Woei; Yang, Ding-Yah Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 843 - 845

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Citation Number: 30

Abstract

Inhibition studies of 4-hydroxyphenylpyruvate dioxygenase (HPPD) with various synthesized 2-o-substituted-benzoyl-and 2-alkanoyl-cyclohexane-1, 3-diones suggest that the presence of a strongly electronegative group at the ortho position and the conformation of the benzene ring moiety on the benzoylcyclohexane-1, 3-dione inhibitors are crucial for potent HPPD inhibition.