A convenient synthesis of 2, 3, 5, 6-tetrahalogenopyridines and of 3, 5-bis (alkylthio) pyridines from 2, 6-diaminopyridine

TK Chen, WT Flowers

Index: Chen, Ted K.; Flowers, William T. Journal of the Chemical Society, Chemical Communications, 1980 , # 23 p. 1139 - 1140

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Citation Number: 11

Abstract

Controlled chlorination of 2, 6-diaminopyridine (1) affords 2, 6-diamino-3, 5-dichloropyridine (2a) which is then bis (diazotised) to give 2, 3, 5, 6-tetrachloropyridine (3a); similarly prepared are other 2, 3, 5, 6-tetra (chloro/bromo) pyridines and 2, 6-dichloro-3, 5-bis (thiocyanato) pyridine (3h), from which 3, 5-bis (alkylthio) pyridines are easily obtained.