Synthesis and immunosuppressive activity of new artemisinin derivatives. 1.[12 (β or α)-dihydroartemisininoxy] phen (ox) yl aliphatic acids and esters
…, Y Sui, JX Wang, JM Wu, Y Zhou, Y Zhang…
Index: Yang, Zhong-Shun; Zhou, Wen-Liang; Sui, Yi; Wang, Jun-Xia; Wu, Jin-Ming; Zhou, Yu; Zhang, Yu; He, Pei-Lan; Han, Ji-Ye; Tang, Wei; Li, Ying; Zuo, Jian-Ping Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4608 - 4617
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Citation Number: 54
Abstract
A series of novel dihydroartemisinin derivatives were synthesized and evaluated on their immunosuppressive activity in the search for potential immunosuppressive agents with high efficacy and low toxicity. These compounds were assayed in their cytotoxicity of lymphocyte, inhibition activity on concanavalin A (ConA) induced T cell proliferation and lipopolysaccharide (LPS) induced B cell proliferation. Among them, 11b, 13b, 14d, 15b, 16 ...
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