Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo [3, 2-d] pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as …

…, CR Kostlan, RB Gilbertsen, MK Bennett…

Index: Sircar; Kostlan; Gilbertsen; Bennett; Dong; Cetenko Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1605 - 1609

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Citation Number: 20

Abstract

CI-950 series, Le., 8-amino-9-substituted-guanines (2), 8* 9 indicated that the N1-nitrogen and C2-NH2 are necessary for activity and potency. The N3-nitrogen is also necessary since 8-amino-3-deazaguaninelo (3) is less potent than 8-aminoguanine. The Ng-nitrogen'seems to be unnecessary for activity and potency since 9-deazainosine"(4), 9-de-