Organic letters

Transition-Metal-Free Synthesis of Oxindoles by Potassium tert-Butoxide-Promoted Intramolecular α-Arylation

A Beyer, J Buendia, C Bolm

Index: Beyer, Astrid; Buendia, Julien; Bolm, Carsten Organic Letters, 2012 , vol. 14, # 15 p. 3948 - 3951

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Citation Number: 54

Abstract

Oxindoles represent an important heterocyclic scaffold that can be found in many natural products.(1) Several of them show significant bioactivities.(2) In the past decades, a wide range of synthetic methods have been developed, giving access to oxindoles with a variety of functionalities. In particular, palladium-catalyzed cyclization reactions, including Mizoroki–Heck couplings,(3) arylations,(4) and alkylations(5) were shown to be useful. Metal-catalyzed ...