Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists

…, S Hibi, H Yoshimura, N Tokuhara, K Tai, T Hida…

Index: Kikuchi, Kouichi; Tagami, Katsuya; Hibi, Shigeki; Yoshimura, Hiroyuki; Tokuhara, Naoki; Tai, Kenji; Hida, Takayuki; Yamauchi, Toshihiko; Nagai, Mitsuo Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1215 - 1218

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Citation Number: 20

Abstract

Although retinoids are thought to have great therapeutic potential, their clinical application is so far limited 3 because of the wide range of toxic effects of retinoids. 4 The diverse actions of retinoids, both desirable and undesirable, reflect the existence of multiple retinoid receptor subtypes. Therefore, subtype-selective retinoids might have potential therapeutical value. In particular, RARα-selective antagonists might be effective in the treatment of airway ...