Journal of medicinal chemistry

Mutagenicity and chemistry of N-nitroso-N-(parasubstituted-benzyl) methylamines

GM Singer, AW Andrews

Index: Singer, George M.; Andrews, A.W. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 309 - 312

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Citation Number: 9

Abstract

Results None of these N-nitroso-N-(p-substituted-benzyl)-methylamines was mutagenic without activation. With activation by the hamster S9 mix, a wide range of mutagenicities was observed. The data from a representative mutagenicity dose-response assay are given in Table 11. Based on the slopes of the dose-response curves (Figure l), the order of mutagenic potency of the test compounds was as follows: p-chloro> p-cyano> p-nitro> p- ...