Preparation of substituted quinolinyl and isoquinolinyl sulfonyl chlorides for the synthesis of novel sulfonamides
JYQ Lai, Y Ferguson, M Jones
Index: Lai, Justine Y. Q.; Ferguson, Yvonne; Jones, Mark Synthetic Communications, 2003 , vol. 33, # 19 p. 3427 - 3433
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Citation Number: 9
Abstract
Chlorosulfonylation of the starting quinoline/isoquinoline was effected by chlorosulfonic acid. Isolation of the sulfonyl chloride was achieved either in a one-step procedure (Method B) or in two-steps via initial isolation of the sulfonic acid (Method A). The isolation of the sulfonic acid was identified by the characteristic stretch in the infrared (ν max 2800–2000 cm −1 ). These were then converted to the sulfonyl chloride in a subsequent step using thionyl chloride ( ...
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