2H-chromene derivatives bearing thiazolidine-2, 4-dione, rhodanine or hydantoin moieties as potential anticancer agents

M Azizmohammadi, M Khoobi, A Ramazani…

Index: Azizmohammadi, Mohammad; Khoobi, Mehdi; Ramazani, Ali; Emami, Saeed; Zarrin, Abdolhossein; Firuzi, Omidreza; Miri, Ramin; Shafiee, Abbas European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 15 - 22

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Citation Number: 59

Abstract

A variety of (Z)-[(2H-chromen-3-yl) methylene] azolidinones 6a–t bearing thiazolidine-2, 4- dione, rhodanine or hydantoin scaffolds were designed and synthesized as potential anticancer agents. Inhibitory effect of synthesized compounds 6a–t on the viability of cancer and non-cancer cells was assessed using MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide) reduction assay. The SAR study revealed that the N- ...