2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression

…, PS Iyer, MC Lucas, R Roetz, RC Schoenfeld…

Index: Carter, David S.; Cai, Hai-Ying; Lee, Eun Kyung; Iyer, Pravin S.; Lucas, Matthew C.; Roetz, Ralf; Schoenfeld, Ryan C.; Weikert, Robert J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 13 p. 3941 - 3945

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Citation Number: 20

Abstract

Recently a class of compounds known as triple reuptake inhibitors has emerged as a new strategy for the treatment of depression. These compounds work by simultaneously inhibiting the synaptic reuptake of serotonin, norepinephrine and dopamine. In this Letter we describe the optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors.