Regioselective addition of Grignard reagents to 1-acylpyridinium salts. A convenient method for the synthesis of 4-alkyl (aryl) pyridines
DL Comins, AH Abdullah
Index: Comins, Daniel L.; Abdullah, Abdul H. Journal of Organic Chemistry, 1982 , vol. 47, # 22 p. 4315 - 4319
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Citation Number: 186
Abstract
Our results show that due to a lack of regioselectivity the reacton of Grignard reagents with 1- acylpyridinium chlorides is limited in scope with regard to the synthesis of 2-alkylpyridines. However, the method may be valuable for the preparation of 2-arylpyridines since aryl Grignard reagents appear to have a greater preference for attack at the 2-position than their aliphatic counterparts. The method is useful for the preparation of 2-substituted 4- ...
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