Quinazolines as cyclin dependent kinase inhibitors

…, H Chen, A Smallwood, CH Chang, M Boisclair…

Index: Sielecki, Thais M.; Johnson, Tricia L.; Liu, Jie; Muckelbauer, Jodi K.; Grafstrom, Robert H.; Cox, Sarah; Boylan, John; Burton, Catherine R.; Chen, Haiying; Smallwood, Angela; Chang, Chong-Hwan; Boisclair, Michael; Benfield, Pamela A.; Trainor, George L.; Seitz, Steven P. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1157 - 1160

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Citation Number: 77

Abstract

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.