Tetrahedron letters

Novel synthesis of sterically hindered N-substituted lactams from imides

M Sannigrahi, P Pinto, TM Chan, NY Shih, FG Njoroge

Index: Sannigrahi, Mousumi; Pinto, Patrick; Chan; Shih, Neng-Yang; George Njoroge Tetrahedron Letters, 2006 , vol. 47, # 28 p. 4877 - 4880

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Citation Number: 8

Abstract

Pyridones are well known pharmacophores and have emerged as potent antitumor, antiviral, and antimicrobial agents over the last decade. 1 During the course of our chemistry program there was a need to synthesize and incorporate these moieties in our scaffold. Unsubstituted pyridones are generally prepared via nucleophilic displacement of an appropriate bromide or mesylate by hydroxypyridine. 2 In our case we used mesylate 1 as the leaving group but ...