The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure–activity …
MB Shaghafi, DG Barrett, FS Willard…
Index: Shaghafi, Michael B.; Barrett, David G.; Willard, Francis S.; Overman, Larry E. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1031 - 1036
Full Text: HTML
Citation Number: 6
Abstract
Abstract We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, 1–3, having the 3-arylhexahydropyrrolo [1, 2-c] pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the ...
Related Articles:
[Kitbunnadaj, Ruengwit; Hashimoto, Takeshi; Poli, Enzo; Zuiderveld, Obbe P.; Menozzi, Alessandro; Hidaka, Ryoko; De Esch, Iwan J. P.; Bakker, Remko A.; Menge, Wiro M. P. B.; Yamatodani, Atsushi; Coruzzi, Gabriella; Timmerman, Henk; Leurs, Rob Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2100 - 2107]
[Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9992 - 9998]