Journal of heterocyclic chemistry

Synthesis of 3??substituted??1??methylpyrazoles

JW Pavlik, EM Kurzweil

Index: Pavlik, James W.; Kurzweil, Edyth M. Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1357 - 1359

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Citation Number: 6

Abstract

Aug-Sept 1992 Synthesis of 3-Substituted-l-methylpyrazoles James W. Pavlik* and Edyth M. Kurzweil Department of Chemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609 Received January 21, 1992 Reaction of 3-bromo-l-methylpyrazole 1 with i-butyllithium at - 100° followed by quenching of the lithio- pyrazole intermediate allows regiospecific introduction of substituents into the 3-position of the 1-methylpy- razole ring. 1357 /. Heterocyclic ...