Potential anticancer agents. V. Aromatic nitrogen mustards related to 3-[N, N-bis (2-chloroethyl) amino]-4-methylbenzoic acid

A Cambanis, V Dobre…

Index: Cambanis,A. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 1 p. 161 - 164

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Citation Number: 9

Abstract

New nitrogen mustards, derivatives of phosphoric and sulfonic aromatic acids, are also reported. relation between hydrolysis rate of these S-mustards and basicity of precurqor amines was established. hancement of the hydrolysis rate due to the steric effect of o-methyl groapq was pointed out. n as tested against Jensen sarcoma, Walker 256 carcinosarcoma, and Gu6rin T8 carcinoma.