Two-Directional Approach for the Rapid Synthesis of 2, 4-Bis-Aminoaryl Pyridine Derivatives

R Morgentin, B Barlaam, K Foote, L Hassall…

Index: Morgentin, Remy; Barlaam, Bernard; Foote, Kevin; Hassall, Lorraine; Hawkins, Janet; Jones, Clifford D.; Le Griffon, Antoine; Peru, Aurelien; Ple, Patrick Synthetic Communications, 2012 , vol. 42, # 1 p. 8 - 24

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Citation Number: 4

Abstract

As part of our continuing interest in promising new scaffolds as inhibitors of kinases, we focused our research on 5-substituted 2,4-bis-aminoaryl pyridines (BAPyds). Very few synthetic methods have been reported in the literature, [ 1 1. Tasler , S. ; Mueller , O. ; Wieber , T. ; Herz , T. ; Krauss , R. ; Totzke , F. ; Kubbutat , MHG ; Schaechtele , C. N-Substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping . Bioorg. Med. Chem. Lett. ...