Tetrahedron

A new 'one-pot'synthesis of hydrazides by reduction of hydrazones

D Perdicchia, E Licandro, S Maiorana, C Baldoli…

Index: Perdicchia, Dario; Licandro, Emanuela; Maiorana, Stefano; Baldoli, Clara; Giannini, Clelia Tetrahedron, 2003 , vol. 59, # 39 p. 7733 - 7742

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Citation Number: 22

Abstract

A new, high-yielding methodology for reducing hydrazones to hydrazines is described, which allows the synthesis of different mono-, di-and trisubstituted hydrazines. Moreover, the reduction step can be followed by an in situ reaction with a carboxylic acid making possible a 'one-pot'synthesis of trisubstituted hydrazides. The method is relatively general and, in principle, suitable for industrial applications.