Univocal syntheses of 2-and 3-hydroxymethyl-2, 3-dihydro [1, 4] dioxino [2, 3-b] pyridine enantiomers

…, M Pallavicini, L Fumagalli, B Moroni, C Rusconi…

Index: Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Moroni, Barbara; Rusconi, Chiara; Valoti, Ermanno Tetrahedron Asymmetry, 2005 , vol. 16, # 20 p. 3380 - 3384

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Citation Number: 3

Abstract

The enantiomers of 2-and 3-hydroxymethyl substituted 2, 3-dihydro [1, 4] dioxino [2, 3-b] pyridine 1 and 2, important chiral building blocks for the preparation of several biologically active compounds, were synthesized.(S)-and (R)-1 were obtained from either one or both the enantiomers of benzylglycerol, while (S)-and (R)-2 were obtained from (R)-and (S)- isopropylideneglycerol, respectively. The novel efficient synthetic strategies, which do not ...