Tetrahedron

New route to herbertanes via a Suzuki cross-coupling reaction: synthesis of herbertenediol

A Abad, C Agulló, AC Cuñat, D Jiménez, RH Perni

Index: Abad, Antonio; Agullo, Consuelo; Cunat, Ana C; Jimenez, Diego; Perni, Remedios H Tetrahedron, 2001 , vol. 57, # 48 p. 9727 - 9735

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Citation Number: 11

Abstract

The synthesis of herbertenediol, a relevant member of the herbertane-type sesquiterpene family, is described. The synthesis is based on a new general approach to this group of sesquiterpenes where the herbertane skeleton is constructed using a Suzuki cross-coupling reaction and a [2, 3]-sigmatropic Still–Wittig rearrangement as key synthetic steps.