Structure–activity relationships for vitamin D3-based aromatic A-ring analogues as Hedgehog pathway inhibitors

AM DeBerardinis, DJ Madden, U Banerjee…

Index: Norman, Mark H.; Rigdon, Greg C.; Hall, William R.; Navas III, Frank Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1172 - 1188

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Citation Number: 10

Abstract

... a Reagents and conditions: (a) DCC, DMAP, DCM, (X)-ArCO 2 H (60–95%); (b) 37 or 38, Pd(OH) 2 (10%), H 2 , MeOH:THF (2:1) (75%); (c) 39, TFA:DCM (1:1) (65%). figure Scheme 3. Hetero- and Biaryl A-Ring Analogues: Subclass II a. ...