The Journal of organic chemistry

Synthesis of Janus compounds for the recognition of GU mismatched nucleobase pairs

G Artigas, V Marchán

Index: Artigas, Gerard; Marchan, Vicente Journal of Organic Chemistry, 2013 , vol. 78, # 21 p. 10666 - 10677

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Citation Number: 7

Abstract

The design and synthesis of two Janus-type heterocycles with the capacity to simultaneously recognize guanine and uracyl in GU mismatched pairs through complementary hydrogen bond pairing is described. Both compounds were conveniently functionalized with a carboxylic function and efficiently attached to a tripeptide sequence by using solid-phase methodologies. Ligands based on the derivatization of such Janus compounds with a ...