Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan

CE Smith, WRN Williamson, CH Cashin…

Index: Smith,C.E. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, # 12 p. 1464 - 1469

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Citation Number: 8

Abstract

Compounds having acenaphthene and indan as their parent nuclei were synthesized for antiinflammatory testing. Compounds which showed activity were 1-phenyl-5- acenaphthenylacetic acid and its a-methyl derivative (carrageenan rat paw edema) and the same a-methylacenaphthenylacetic acid and 2-(4-chlorobenzylidene)-3-oxo-5-indanacetic acid and its a-methyl derivative (rat adjuvant arthritis). None of the compounds was more ...