Synthesis and Incorporation into Cyclic Peptides of Tolan Amino Acids and Their Hydrogenated Congeners: Construction of an Array of A–B-loop Mimetics of the Cε3 …

…, MD Holdom, BA Helm, RJ Leatherbarrow…

Index: Offermann, Daniel A.; McKendrick, John E.; Sejberg, Jimmy J. P.; Mo, Bingli; Holdom, Mary D.; Helm, Birgit A.; Leatherbarrow, Robin J.; Beavil, Andrew J.; Sutton, Brian J.; Spivey, Alan C. Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3197 - 3214

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Citation Number: 13

Abstract

The disruption of the human immunolobulin E–high affinity receptor I (IgE–FcεRI) protein– protein interaction (PPI) is a validated strategy for the development of anti asthma therapeutics. Here, we describe the synthesis of an array of conformationally constrained ...