Tetrahedron letters

Efficient preparation of chiral diamines via Red-Al reduction of N-Boc-protected amino acid-derived secondary amides

EA Voight, MS Bodenstein, N Ikemoto, MH Kress

Index: Voight, Eric A.; Bodenstein, Matthew S.; Ikemoto, Norihiro; Kress, Michael H. Tetrahedron Letters, 2006 , vol. 47, # 11 p. 1717 - 1720

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Citation Number: 16

Abstract

Conditions have been developed for the selective reduction of N-Boc-protected amino acid- derived secondary amides, avoiding the formation of overreduction and cyclic urea byproducts. The method is showcased by the efficient formal synthesis of NK-1 antagonist LY303870.