Facile Substitution of N, N-Dimethylanilines and Phenols with Trifluoroacetaldehyde Ethyl Hemiacetal
Y Gong, K Kato, H Kimoto
Index: Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi Synlett, 1999 , # 9 p. 1403 - 1404
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Citation Number: 10
Abstract
Abstract: 2, 2, 2-Trifluoro-1-(N, N-dimethylaminophenyl) ethanols were easily formed in excellent yields by electrophilic substitution between N, N-dimethylanilines 1a, b and trifluoroacetaldehyde ethyl hemiacetal (TFAE). The corresponding substitution of phenols 2a- e to prepare 2, 2, 2-trifluoro-1-(hydroxyphenyl) ethanols, however, occurred only in the presence of catalytic amounts of anhydrous potassium carbonate. Key words: a- ...
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