N-substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor

KH Ahn, SJ Lee, CH Lee, CY Hong, TK Park

Index: Ahn, Kyo Han; Lee, Seok Jong; Lee, Chang-Ho; Hong, Chang Y.; Park, Tae Kyo Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1379 - 1384

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Citation Number: 19

Abstract

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy) pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3- arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino) butyl] pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for ...