Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

B Desai, D Dallinger, CO Kappe

Index: Desai, Bimbisar; Dallinger, Doris; Kappe, C. Oliver Tetrahedron, 2006 , vol. 62, # 19 p. 4651 - 4664

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Citation Number: 84

Abstract

Multifunctionalized dihydropyrimidine-5-carboxylic amides and esters are generated in a multistep sequence integrating a variety of enabling and high throughput technologies such as automated or parallel microwave synthesis, the use of polymer-supported reagents, fluorous synthesis and purification strategies, and a continuous flow hydrogenation system. The key dihydropyrimidine-5-carboxylic acid intermediates are obtained in two steps by ...