Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy

S Kimura, S Masunaga, T Harada, Y Kawamura…

Index: Kimura, Sadaaki; Masunaga, Shin-Ichiro; Harada, Tomohiro; Kawamura, Yasuo; Ueda, Satoshi; Okuda, Kensuke; Nagasawa, Hideko Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1721 - 1728

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Citation Number: 11

Abstract

Boron-containing agents play a key role in successful boron neutron capture therapy (BNCT). Icosahedral boron cluster-Arg-Gly-Asp (RGD) peptide conjugates were designed, synthesized, and evaluated for the biodistribution to develop tumor-selective boron carriers. Integrin αvβ3 is an attractive target for anti-tumor drug delivery because of its specific expression in proliferating endothelial and tumor cells of various origins. We, therefore, ...