A method for the stereoselective synthesis of (E)-methylstilbene retinoids

MI Dawson, K Derdzinski, PD Hobbs…

Index: Dawson; Derdzinski; Hobbs; et al. Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5265 - 5267

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Citation Number: 9

Abstract

The E isomers of stilbenes 3 are a new class of aromatic retinoids that has shown promising activity in controlling the differentiation of epithelial cells and, therefore, may have potential therapeutic value in the treatment of such proliferative diseases of the skin as cancer, psoriasis, and Highly stereoselective syntheses of (E)-3 are desirable because the E and Z isomers in this series are frequently difficult to separate. We have investigated the ...