N-Pantoyl-(substituted-phenyl) alkylamines, Inhibitory Analogs of Pantothenic Acid1, 2

ED Parker, TJ Cogdell, JS Humphreys…

Index: Parker,E.D. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 73 - 76

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Citation Number: 9

Abstract

The syntheses of nineteen new X-pantoyl-(substituted-pheny1) alkylamines were accomplished by the condensation of the appropriate amines with pantolactone. Using Lactobacillus arabinosus 17-5 and Leuconoatoc mesenteroides P-60 as the test organisms, all of the derivatives were found to be competitive inhibitors of the utilization of pantothenic acid. For L. mesenteroides, a p-chloro substituent increased the inhibitory activity of the ...