Synthesis of 2-phenylthiazolidine derivatives as cardiotonic agents. IV. Modification of the phenylpiperazino moiety of 2-(phenylpiperazinoalkoxyphenyl) thiazolidine-3 …

H NATE, A WATANABE, K MATSUKI, I INOUE…

Index: Nate; Watanabe; Matsuki; Inoue; Ohtsuka; Sekine; Oda; Honma; Ishida; Kanno Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 7 p. 2825 - 2839

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Citation Number: 4

Abstract

Examination of the structure-activity relationships of 2-(phenylpiperazinoalkoxyphenyl)- thiazolidine-3-carbothioamides and the corresponding carboxamides (1) as new cardiotonic agents was extended by the chemical modification of the phenylpiperazino moiety. The 4- phenylpiperidine (13), 4-phenyltetrahydropyridines (17), and related derivatives were prepared from the chlorides (10) through several intermediates (12, 14, and 16) and ...