Discovery of thienopyridines as Src-family selective Lck inhibitors

…, A Burchat, DJ Calderwood, H Davis, P Hrnciar…

Index: Abbott, Lily; Betschmann, Patrick; Burchat, Andrew; Calderwood, David J.; Davis, Heather; Hrnciar, Peter; Hirst, Gavin C.; Li, Biqin; Morytko, Michael; Mullen, Kelly; Yang, Bryant Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1167 - 1171

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Citation Number: 26

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck. ... We describe the identification, SAR, and in vivo ...

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