Non-amine based analogs of lavendustin A as protein-tyrosine kinase inhibitors

MS Smyth, I Stefanova, F Hartmann…

Index: Smyth, Mark S.; Stefanova, Irena; Hartmann, Frank; Horak, Ivan D.; Osherov, Nir; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 3010 - 3014

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Citation Number: 49

Abstract

The fermentation product lavendustin A (1) is a protein-tyrosine kinase (PTK) inhibitor whose active pharmacophore has previously been shown to reside in the more simplified salicyl- containing benzylamine 2. Amine 2 bears some structural resemblance to two other natural product PTK inhibitors, erbstatin (3) and piceatannol (4). Non-amine containing analogues of 2 were therefore synthesized which incorporated additional aspects of either erbstatin ...