5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals

…, H Karoui, B Tuccio, FL Moigne, M Culcasi…

Index: Frejaville, Claudine; Karoui, Hakim; Tuccio, Beatrice; Moigne, Francois Le; Culcasi, Marcel; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 258 - 265

Full Text: HTML

Citation Number: 455

Abstract

5-(Diethoxyphosphory1)-5-methyl-l-pyrroline N-oxide (DEPMPO, 2), a new spin trap, has been synthesized via a two-step synthetic route, and its ability to spin trap oxy radicals in biological milieu has been addressed. The in vitro spin trapping of hydroxyl and superoxide radicals was investigated in a phosphate buffer 0.1 M, and the hyperfine coupling constants of the spin adducts were determined. The rates of spin trapping of hydroxyl and ...