Improved synthesis for the rodenticides, diphenacoum and brodifacoum
PS van Heerden, BCB Bezuidenhoudt…
Index: Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
Full Text: HTML
Citation Number: 24
Abstract
An improved synthesis of the 3-[3-(p-substituted phenyl)-1, 2, 3, 4-tetrahydro-1-napththyl]-4- hydroxycoumarins, diphenacoum and brodifacoum, is described. The process is primarily based on the formation of one of the crucial bonds in the carbon backbone using organocopper methodology, and on the coupling of the 4-hydroxycoumarin moiety to the 3- biphenyl tetralin unit under strongly acidic conditions.
Related Articles:
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
[Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531]
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
[Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531]
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
[Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531]
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
[Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531]
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
[Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531]