Studies on Agents with Vasodilator and β-Blocking Activities. II

…, Y TANIMOTO, T YAMAGUCHI, N SAITOH…

Index: Seki; Takezaki; Ohuchi; Ohuyabu; Tanimoto; Yamaguchi; Saitoh; Ishimori; Yasuda Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 2 p. 247 - 255

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Abstract

A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anethetized rats. Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.