Tetrahedron letters

Chiral aminal termplates 6 1. Diastereoselectivity of hydrazone alkylation. Asymmetric synthesis of α-aminoaldehydes

A Alexakis, N Lensen, P Mangeney

Index: Alexakis, Alexandre; Lensen, Nathalie; Mangeney, Pierre Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1171 - 1174

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Citation Number: 56

Abstract

Glyoxal is efficiently transformed into the chiral animals bearing the hydrazone functionality and . These compounds react under complete diastereocontrol with various organolithium reagents, affording chiral hydrazines – . Reduction with Raney nickel leads to aminal protected α-aminoaldehydes, which, in turn, are easily hydrolyzed to the free chiral aldehydes (after tBoc protection of the amine). ... Cookies are used by this site. To decline or learn more, visit ...

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