Conversion of a ketone to a geminal bisacetamide: synthesis of 1, 1-bisacetamidocyclohexane

MC Davis, D Stasko, RD Chapman

Index: Davis, Matthew C.; Stasko, Daniel; Chapman, Robert D. Synthetic Communications, 2003 , vol. 33, # 15 p. 2677 - 2684

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Citation Number: 10

Abstract

View all references we required a route to gem-bisacetamides. Although aldehydes will condense with carboxamides to furnish the corresponding aldoaminals,2–4 View all references protected ketoaminals derived from ketones are not well known. One example was a bisacetamide made by the Ritter reaction on a specific bicyclic ketone, 5,5,6-trimethylbicyclo[2.2.1]heptan-2-one,[5a ]5. Kozlov , NG , Popova , LA , Biba , VI , Potkina , TN and Korshuk , É.F. 1988. Reaction of ...