Tetrahedron letters

Synthesis of C1–C20 and C21–C40 fragments of tetrafibricin

V Gudipati, DP Curran

Index: Gudipati, Venugopal; Curran, Dennis P. Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2254 - 2257

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Citation Number: 9

Abstract

Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski–Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner–Wadsworth– Emmons reaction.