… . 2. Synthesis of enantiomerically pure prostaglandin intermediates by Enzymatic Hydrolysis of (1SR, 5RS, 6RS, 7RS)??7??acetoxy??6??acetoxymethyl??2??oxabicyclo [3.3. …

F Theil, H Schick, P Nedkov, M Böhme…

Index: Theil, Fritz; Schick, Hans; Nedkov, Peter; Boehme, Monika; Haefner, Barbara; Schwarz, Sigfrid Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 893 - 899

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Citation Number: 7

Abstract

Abstract Subtilisin DY as well as alkaline protease from Bacillus licheniformis 41 p catalyze the hydrolysis of (1SR, 5RS, 6RS, 7RS)-7-acetoxy-6-acetoxymethyl-2-oxabicyclo [3.3. 0] octan-3-one (rac-1) with practically useful enantio-and regioselectivity. Under the hitherto found optimal conditions (1S, 5R, 6R, 7R)-7-hydroxy-6-hydroxymethyl-2-oxabicyclo [3.3. 0] octan-3-one (4), an important intermediate in prostaglandin syntheses, could be prepared ...