Salicylanilides as inhibitors of the protein tyrosine kinase epidermal growth factor receptor

…, U Séquin, G Bold, P Furet, T Meyer, P Traxler

Index: Liechti, Christoph; Sequin, Urs; Bold, Guido; Furet, Pascal; Meyer, Thomas; Traxler, Peter European Journal of Medicinal Chemistry, 2004 , vol. 39, # 1 p. 11 - 26

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Citation Number: 68

Abstract

A pharmacophore model for ATP-competitive inhibitors interacting with the active site of the EGFR protein tyrosine kinase and a putative binding mode of 4-anilinoquinazoline suggest that a salicylic acid function could serve as the pharmacophore replacement of a pyrimidine ring. Superpositions by CAMM of salicylanilides with the potent EGFR tyrosine kinase inhibitor 4-[(3′-chlorophenyl) amino]-6, 7-dimethoxyquinazoline showed that ...