Design and synthesis of a nucleoside and a phosphonate analogue constructed on a branched-threo-tetrofuranose skeleton

…, H Wakamatsu, Y Natori, H Takahata, Y Yoshimura

Index: Kiran; Wakamatsu, Hideaki; Natori, Yoshihiro; Takahata, Hiroki; Yoshimura, Yuichi Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3949 - 3952

Full Text: HTML

Citation Number: 2

Abstract

The synthesis of a novel nucleoside phosphonate constructed on a branched-threo- tetrofuranose scaffold, as a potential antiviral agent, is described. The pseudosugar moiety served as the nucleoside skeleton was produced starting from 2-butyne-1, 4-diol in 10-steps. Glycosylation with the pseudosugar involved stereoselective neighboring group participation of p-anisyl group and gave the nucleoside derivative in 94% yield. After ...