Protonation of trimipramine salts of maleate, mesylate and hydrochloride observed by 1H, 13C and 15N NMR spectroscopy

BS Somashekar, GA Nagana Gowda…

Index: Somashekar; Nagana Gowda; Ramesha; Khetrapal Magnetic Resonance in Chemistry, 2005 , vol. 43, # 2 p. 166 - 170

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Citation Number: 3

Abstract

Abstract Protonation of the tricyclic antidepressant drug trimipramine with maleic acid, methanesulfonic acid and hydrochloric acid was studied using 1 H, 13 C and 15 N NMR spectroscopy at natural abundance. The effect of counter ions on the protonation was compared under identical conditions of solvent, concentration and temperature using homonuclear and heteronuclear one-and two-dimensional experiments. Differential ...